Role for multiple sequential ALK inhibitors
Secondary ALK mutation
Fribroulet, et al. Cancer Discov 2012; Katayama, et al. Clin Cancer Res 2014; Ou, et al. J Thorac Oncol 2014
Ou, et al. Lung Cancer 2016; Gainor, et al. Cancer Discov 2016
F1174V
F1174V
Ceritinib
PD
Crizotinib
Alectinib
Therapy
Crizotinib
PD
Alectinib
2
L
1L
Ceritinib
3L
PD
I1171T
Therapy
INDICACIÓN NO APROBADA, EN INVESTIGACIÓN
