Eribulin
(N=544)
Capecitabine
(N=546)
All Grades
Grade ≥3
All Grades
Grade ≥3
%
%
%
%
Fatigue
16.7
2.0
15.4
2.4
Asthenia
15.3
4.2
14.5
3.7
Pyrexia
12.9
0.4
5.7
0.5
Nausea
22.2
0.2
24.4
1.6
Diarrhoea
14.3
1.1
28.8
5.3
Vomiting
11.9
0.4
16.8
2.2
Alopecia
34.6
-
4.0
-
Hand-foot syndrome
0.2
-
45.1
14.5
Peripheral sensory neuropathy
13.4
3.5
7.0
0.5
Headache
12.7
0.7
10.4
0.6
Back pain
10.3
1.5
7.9
0.5
Dyspnoea
10.3
2.9
10.8
4.4
Decreased appetite
12.5
0.6
14.8
1.6
Study 301: Non-Haematologic Adverse Events
Incidence >10% (All Grades) or 1% (Grade 3 or Higher) in Either Arm
Safety Population
If a subject had two or more adverse events in the same system organ class or with the same preferred term with
different CTCAE grades, then the event with the highest grade was used for that subject.
