Caution: drug-drug interactions
Drug
Interaction
Abiraterone
• Inhibitor of CYP2D6 and CYP2C8
o
Caution when co-administered with drugs metabolized by CYP2D6 (eg, metoprolol,
propranolol, haloperidol, codeine, oxycodone)
•
Avoid strong inducers of CYP3A4 (eg, enzalutamide)
• Caution with drugs known to prolong the QT interval
• Concomitant use with spironolactone not recommended
Enzalutamide •
Strong inducer of CYP3A4
; moderate inducer of CYP2C9 and CYP2C19
• CYP2C8 plays important role in elimination of enzalutamide; strong inhibitors (eg, gemfibrozil) to
be avoided
• Caution with many products (eg, analgesics, antibiotics, anticancer agents, anticoagulants,
antiepileptics, antipsychotics, beta blockers, calcium channel blockers, cardiac glycosides,
corticosteroids, HIV antivirals, hypnotics, statins metabolized by CYP3A4, thyroid agents)
•
Caution with cabazitaxel
• Caution with drugs known to prolong the QT interval
Cabazitaxel
• Co-administration with strong CYP3A inhibitors (eg, ketoconazole) and inducers (eg, phenytoin,
rifapentin, phenobarbital) should be avoided
•
Caution with enzalutamide
From
. (Accessed 31 Nov 2016).
SAEU.CAB.16.07.0040j
