Tolerability in senior adults
Main adverse events in men aged ≥75 yrs
Abiraterone acetate [1-3] Fatigue/asthenia, hypokalemia, hypertension, hepatotoxicity, cardiac
disorders, peripheral oedema
Enzalutamide [1, 4]
Fatigue/asthenia, constipation, hot flushes, falls, fractures, hypertension,
headache, memory impairment
Docetaxel [1, 6]
Neutropenic complications, anemia, fatigue/asthenia, diarrhea, neuropathy,
oedema, anorexia, nail disorders
Cabazitaxel [1, 7-8]
Neutropenic complications, anemia, fatigue, diarrhea, nausea, vomiting,
decreased appetite
Radium 223 [1, 9-10]*
Anemia, thrombocytopenia, diarrhea
1.
; 2. Smith MR et al. J Urol 2015;94:1277-84; 3. Sternberg C et al. Lancet Oncol 2014;15:1263–68; 4. Sternberg C et al. Ann Oncol 2014;25:429-34;
5. Horgan AM et al. J Geriatr Oncol 2014;5:119-26; 6. Sartor AO et al. J Clin Oncol 2016;34(suppl):abstract 5006 - ClinicalTrials.gov NCT01308567; 7. Heidenreich A et al. Eur J Cancer
2014;50:1090-9; 8. Hoskin P et al. Lancet Oncol 2014;15:1397-406; 9. Saad F et al. Lancet Oncol 2016;17:1306-16
*No specific analysis in patients aged ≥75 years
SAEU.CAB.16.07.0040j
