OS PD-L1 TPS ≥50% Stratum
Analysis cut-off date: September 30, 2015.
Treatment Arm
Median
(95% CI), mo
HR
a
(95% CI)
P
Pembro 2 mg/kg
14.9 (10.4-NR) 0.54 (0.38-0.77) 0.0002
Pembro 10 mg/kg 17.3 (11.8-NR) 0.50 (0.36-0.70) <0.0001
Docetaxel
8.2 (6.4-10.7)
—
—
a
Comparison of pembrolizumab vs docetaxel.
0
5
10
15
20
25
0
10
20
30
40
50
60
70
80
90
100
Time, months
Overall
Survival, %
139
151
152
110
115
90
51
60
38
20
25
19
3
1
1
0
0
0
2 vs 10 mg/kg:
HR 1.12, 95% CI 0.77-1.62
Herbst RS et al.
Lancet
2016; 387: 1540–1550 (and online appendix).
