28
        
        
          Investigator’s Choice (n = 61)
        
        
          Nivolumab (n = 88)
        
        
          PD-L1 ≥ 1%
        
        
          PD-L1 < 1%
        
        
          HR (95% CI)
        
        
          0.55 (0.36, 0.83)
        
        
          Overall Survival (% of patients)
        
        
          Nivolumab (n = 73)
        
        
          Investigator’s Choice (n = 38)
        
        
          HR (95% CI)
        
        
          0.89 (0.54, 1.45)
        
        
          Months
        
        
          0
        
        
          3
        
        
          6
        
        
          9
        
        
          12
        
        
          15
        
        
          18
        
        
          0
        
        
          10
        
        
          20
        
        
          30
        
        
          40
        
        
          50
        
        
          60
        
        
          70
        
        
          80
        
        
          90
        
        
          100
        
        
          Overall Survival (% of patients)
        
        
          Nivolumab
        
        
          Investigator’s
        
        
          Choice
        
        
          No. at Risk
        
        
          88
        
        
          67
        
        
          44
        
        
          61
        
        
          42
        
        
          20
        
        
          18
        
        
          6
        
        
          6
        
        
          2
        
        
          0
        
        
          0
        
        
          73
        
        
          52
        
        
          33
        
        
          0
        
        
          38
        
        
          29
        
        
          14
        
        
          0
        
        
          17
        
        
          6
        
        
          8
        
        
          2
        
        
          3
        
        
          0
        
        
          Months
        
        
          0
        
        
          3
        
        
          6
        
        
          9
        
        
          12
        
        
          15
        
        
          18
        
        
          0
        
        
          10
        
        
          20
        
        
          30
        
        
          40
        
        
          50
        
        
          60
        
        
          70
        
        
          80
        
        
          90
        
        
          100
        
        
          Overall Survival by Tumor PD-L1 Expression at 1%
        
        
          Nivolumab in R/M SCCHN After Platinum Therapy