Is classification by side an over-simplification?
Distribution of molecular characteristics varies
Across colorectal cancer subsites
•
Yamauchi M, et al. Gut 2012;61:847–54.
50
40
30
20
10
0
Caecum
(n = 243)
Ascending
colon
(n = 295)
Hepatic
flexure
(n = 46)
Transverse
colon
(n = 91)
Splenic
flexure
(n = 33)
Descending
colon
(n = 83)
Sigmoid
colon
(n = 314)
Rectosigmoid
(n = 106)
Rectum
(n = 232)
CIMP-high
MSI-high
BRAF
mutation
Proportion of positive cases (%)
Variation in molecular characteristics across bowel subsites challenges the concept of discrete right colon and left
colorectal tumour characteristics
